Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling

Promoting PGC1α-driven Mitochondrial Biogenesis Is

1 Detrimental In Pressure Overloaded Mouse Hearts 2 3 Georgios Karamanlidis*, Lorena Garcia-Menendez*, Stephen C. Kolwicz, Jr., Chi Fung 4 Lee, Rong Tian. 5 Mitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, 6 University of Washington, Seattle, Washington, USA. 7 Running title: PGC1α overexpression in cardiac pressure overload 8 9 Corresponding author: 10 Rong Tia...

Selenite Stimulates Mitochondrial Biogenesis Signaling and Enhances Mitochondrial Functional Performance in Murine Hippocampal Neuronal Cells

Supplementation of selenium has been shown to protect cells against free radical mediated cell damage. The objectives of this study are to examine whether supplementation of selenium stimulates mitochondrial biogenesis signaling pathways and whether selenium enhances mitochondrial functional performance. Murine hippocampal neuronal HT22 cells were treated with sodium selenite for 24 hours. Mito...

Mitochondrial biogenesis in cardiac pathophysiology.

Cardiac performance depends on a fine balance between the work the heart has to perform to satisfy the needs of the body and the energy that it is able to produce. Thus, energy production by oxidative metabolism, the main energy source of the cardiac muscle, has to be strictly regulated to adapt to cardiac work. Mitochondrial biogenesis is the mechanism responsible for mitochondrial component s...

GPS2 regulates mitochondria biogenesis via mitochondrial retrograde signaling and chromatin remodeling of nuclear-encoded mitochondrial genes

5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis.

Mitochondrial dysfunction is both a cause and target of reactive oxygen species during ischemia-reperfusion, drug, and toxicant injury. After injury, renal proximal tubular cells (RPTC) recover mitochondrial function by increasing the expression of the master regulator of mitochondrial biogenesis, peroxisome-proliferator-activated-receptor-gamma-coactivator-1alpha (PGC-1alpha). The goal of this...